Internal medicine (Tokyo, Japan) · 2023
Hepatitis C Virus-associated Cryoglobulinemic Livedo Reticularis Improved with Direct-acting Antivirals.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yokoyama Keiji, Kino Tomohiro, Nagata Takahiro, Miyayama Takashi, Shibata Kumiko, Fukuda Hiromi, Yamauchi Ryo, Fukunaga Atsushi, Umeda Kaoru, Takata Kazuhide, Tanaka Takashi, Shakado Satoshi, Sakisaka Shotaro, Imafuku Shinichi, Hirai Fumihito
Аннотация
We herein report a case of hepatitis C virus (HCV)-associated cryoglobulinemic livedo reticularis in a woman in her 60s that improved with direct-acting antivirals (DAAs). Hyperpigmentation was observed in both lower legs, and a skin biopsy confirmed livedo reticularis, suggesting a relationship with cryoglobulinemia and HCV infection. DAAs with an NS5A inhibitor+NS3/4A protease inhibitor (glecaprevir/pibrentasvir) were administered for eight weeks, and a sustained virological response (SVR) was obtained. The disappearance of serum cryoglobulin was confirmed approximately two years after an SVR was obtained and livedo reticularis was improved. DAA therapy can be an effective therapeutic option for extrahepatic complications associated with HCV infection.