Inflammation · 2020
CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease.
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Liu Qicai, Lin Yunfeng, Zhang Sheng, Chen Min, Chen Qingquan, Rui Hongbin, Wang Fang, Lv Xiaoting, Gao Feng
Аннотация
Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD. In vivo, the levels of prolactin and Th2 cytokines in CGRP+/- rats were higher than those in wild-type. Our findings indicate that the presence of CGRP-deficiency-mediated MAG antibodies is a probable molecular basis for the initial events which were triggered in IgG4-RD immune responses via prolactin upregulation.