Effect of Linguizhugan decoction on hyperlipidemia rats with intermittent fasting.

OBJECTIVE

To explore the effect of Linguizhugan decoction on hyperlipidemia rats with caloric restriction.

METHODS

The hyperlipidemia model of rat was induced by high fat diet for 8 weeks. After the model was established, 26 rats were randomly divided into 4 groups: the control group (n = 6), the model group (n = 6), the intermittent fasting (IF) group (n = 8), and the IF and herbal medicine (IFH) group (n = 6). IF group was applied intermittent fasting every other day. The IFH group was given Linguizhugan decoction every day and intermittent fasting every other day. Blood samples were taken at the end of 16 weeks, and serum ghrelin and lipid was tested.

RESULTS

Serum ghrelin in the IF group significantly increased (P < 0.01). Serum ghrelin in IFH group was lower than the IF group (P < 0.05), but higher than the model group (P < 0.01).

CONCLUSION

Linguizhugan decoction may play a part in regulation of energy and appetite in hyperlipidemia rats with IF.