Hyperprolactinemia in a patient with Sheehan's syndrome.

I have reported the case of a woman with Sheehan's syndrome who had hyperprolactinemia rather than prolactin deficiency. The patient showed no increase in serum thyrotropin in response to TRH challenge and failed to show a normal increase in serum GH and cortisol after insulin-induced hypoglycemia. A blunted FSH response to LH-RH stimulation was also found. A CT scan of the sella showed no adenoma. The patient responded to prednisolone and thyroxine replacement therapy. When, a few months later, the dose of thyroxine was reduced to a suboptimal level, the hyperprolactinemia recurred.