Glia get RIPped in ALS.

While neuroinflammatory responses driven by microglia and astrocytes have been extensively linked to neurodegenerative disease progression in amyotrophic lateral sclerosis (ALS), the specific pathways that coordinate glial cell-dependent neuroinflammation in ALS remain poorly defined. In this issue of Immunity, Zelic et al.1 identified RIPK1 as a pivotal regulator of glial cell-driven neuroinflammation in multiple ALS models.