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Войти в исследования Eye (London, England) · 2026
Choroidal vascularity profiles in diabetic macular oedema subtypes: a swept-source OCT angiography study.
СтатьяНазвание и аннотация: Перевод в очереди
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Ren Lanxin, Yi Jingsheng, Wang Yifan, Zheng Dezhi, Huang Zijing, Chen Weiqi, Huang Dingguo
Аннотация
OBJECTIVES: To characterise choroidal microvascular changes in diabetic macular oedema (DMO) subtypes using swept-source optical coherence tomography angiography (SS-OCTA).
METHODS: This cross-sectional study analysed 182 eyes with centre-involved DMO from 141 patients (45 diffuse retinal thickening [DRT], 72 cystoid macular oedema [CMO], 65 serous retinal detachment [SRD]) and 40 age-matched healthy controls. Imaging was performed using the VG200 SS-OCTA system with a 1050 nm wavelength and 200,000 A-scans/second scan speed. Parameters including choroidal thickness (ChT), choroidal volume (CV), choroidal vascularity index (CVI), and choriocapillaris flow deficit percentage (CC FD%) were assessed in three macular annular regions (1-, 3-, and 6-mm diameter rings cantered on the fovea).
RESULTS: Compared to controls, all DMO subtypes exhibited choroidal microvascular dysfunction, including reduced CVI and increased ChT. Notably, SRD demonstrated the most severe flow deficits, with significantly larger CC FD% than both DRT (17.08 ± 10.83% vs 11.08 ± 7.38%, p = 0.002) and CMO (17.08 ± 10.83% vs 12.71 ± 8.16%, p = 0.014) in the 1-mm diameter ring. Similar differences were observed in the 3-mm diameter ring (SRD 12.66 ± 5.73% vs DRT 9.09 ± 5.00%, p = 0.002; SRD vs CMO 9.84 ± 5.11%, p = 0.007) and 6-mm diameter ring (SRD 9.87 ± 4.03% vs DRT 8.11 ± 4.40%, p = 0.003; SRD vs CMO 8.28 ± 4.07%, p = 0.026). No significant inter-subtype differences were found in CVI or ChT (p > 0.05).
CONCLUSIONS: Choroidal microvascular dysfunction is present in all DMO subtypes, with SRD exhibiting the most severe choriocapillaris flow deficits. These findings suggest potential subtype-specific pathophysiological associations.
METHODS: This cross-sectional study analysed 182 eyes with centre-involved DMO from 141 patients (45 diffuse retinal thickening [DRT], 72 cystoid macular oedema [CMO], 65 serous retinal detachment [SRD]) and 40 age-matched healthy controls. Imaging was performed using the VG200 SS-OCTA system with a 1050 nm wavelength and 200,000 A-scans/second scan speed. Parameters including choroidal thickness (ChT), choroidal volume (CV), choroidal vascularity index (CVI), and choriocapillaris flow deficit percentage (CC FD%) were assessed in three macular annular regions (1-, 3-, and 6-mm diameter rings cantered on the fovea).
RESULTS: Compared to controls, all DMO subtypes exhibited choroidal microvascular dysfunction, including reduced CVI and increased ChT. Notably, SRD demonstrated the most severe flow deficits, with significantly larger CC FD% than both DRT (17.08 ± 10.83% vs 11.08 ± 7.38%, p = 0.002) and CMO (17.08 ± 10.83% vs 12.71 ± 8.16%, p = 0.014) in the 1-mm diameter ring. Similar differences were observed in the 3-mm diameter ring (SRD 12.66 ± 5.73% vs DRT 9.09 ± 5.00%, p = 0.002; SRD vs CMO 9.84 ± 5.11%, p = 0.007) and 6-mm diameter ring (SRD 9.87 ± 4.03% vs DRT 8.11 ± 4.40%, p = 0.003; SRD vs CMO 8.28 ± 4.07%, p = 0.026). No significant inter-subtype differences were found in CVI or ChT (p > 0.05).
CONCLUSIONS: Choroidal microvascular dysfunction is present in all DMO subtypes, with SRD exhibiting the most severe choriocapillaris flow deficits. These findings suggest potential subtype-specific pathophysiological associations.