Respiratory medicine · 2025
Exploring the genetic effects of exposure to hazardous workplaces on the risk of respiratory disease by two-sample mendelian randomization and bioinformatics analysis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wang Chao, Yu Xiao, Guo Xiaoping, Yu Xin, Wang Fang
Аннотация
BACKGROUND: Harsh workplace can include very cold, hot, and dusty workplaces, as well as exposure in the workplace with chemicals and other fumes, cigarette smoke, and diesel exhaust. There is a shortage of genetic evidence regarding the impact of harsh workplaces on respiratory health.
OBJECTIVE: This study aims to investigate the genetic association between harsh workplace and respiratory diseases.
METHODS: This study used two-sample Mendelian randomization analysis based on UK Biobank, FinnGen Project, and IEU Open GWAS Database to exclude confounding factors and investigate the association between workplace and respiratory diseases.
RESULTS: Frequent exposure to workplace with cigarette smoke increased the risk of allergic rhinitis (βIVW = 1.83, P = 0.022). Intermittent exposure to extremely cold workplaces exacerbated asthma (βIVW = 0.34, P = 0.011) and COPD (βIVW = 0.80, P = 0.002). Rare (βMR = 1.15, P = 0.037) or intermittent exposure (βIVW = 0.59, P = 0.019) to extremely hot workplaces may worsen COPD. Chemical/smoke exposure may aggravate emphysema (βIVW = 0.03, P = 0.016). Exposure to extremely hot (βIVW = 0.90, P = 0.016) and dusty workplaces (βIVW = 0.97, P = 0.005) increased lung cancer risk. Exposure to extremely cold workplaces was associated with pneumoconiosis (βIVW = 3.99, P = 0.028) and was a significant risk factor for IPF (βIVW = 3.28, P = 0.015). Rare (βIVW = 1.69, P = 0.011) or frequent exposure (βIVW = 1.44, P = 0.013) to dusty workplaces increased tuberculosis risk.
CONCLUSIONS: Our study excluded other confounding factors and revealed a causal relationship between harsh workplaces and respiratory disease from genetic inheritance. Incorporating genetic evidence into occupational health assessments helps accurately identify high-risk individuals, develop personalized intervention plans, and enhance the effectiveness of respiratory health protection for workers.
OBJECTIVE: This study aims to investigate the genetic association between harsh workplace and respiratory diseases.
METHODS: This study used two-sample Mendelian randomization analysis based on UK Biobank, FinnGen Project, and IEU Open GWAS Database to exclude confounding factors and investigate the association between workplace and respiratory diseases.
RESULTS: Frequent exposure to workplace with cigarette smoke increased the risk of allergic rhinitis (βIVW = 1.83, P = 0.022). Intermittent exposure to extremely cold workplaces exacerbated asthma (βIVW = 0.34, P = 0.011) and COPD (βIVW = 0.80, P = 0.002). Rare (βMR = 1.15, P = 0.037) or intermittent exposure (βIVW = 0.59, P = 0.019) to extremely hot workplaces may worsen COPD. Chemical/smoke exposure may aggravate emphysema (βIVW = 0.03, P = 0.016). Exposure to extremely hot (βIVW = 0.90, P = 0.016) and dusty workplaces (βIVW = 0.97, P = 0.005) increased lung cancer risk. Exposure to extremely cold workplaces was associated with pneumoconiosis (βIVW = 3.99, P = 0.028) and was a significant risk factor for IPF (βIVW = 3.28, P = 0.015). Rare (βIVW = 1.69, P = 0.011) or frequent exposure (βIVW = 1.44, P = 0.013) to dusty workplaces increased tuberculosis risk.
CONCLUSIONS: Our study excluded other confounding factors and revealed a causal relationship between harsh workplaces and respiratory disease from genetic inheritance. Incorporating genetic evidence into occupational health assessments helps accurately identify high-risk individuals, develop personalized intervention plans, and enhance the effectiveness of respiratory health protection for workers.