Zhonghua nei ke za zhi · 1999
[Extensive HLA class II studies in Chinese narcoleptic patients].
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Xiao Y, Huang X, Qiu C, Zhu X, Liu Y
Аннотация
OBJECTIVE: Narcolepsy is a debilitating, lifelong sleep disorder. Its familial occurrence suggests that genetic factors may be of importance in the etiology. Narcolepsy is a very rare disease among Chinese, thus it was of interest to study the association of narcolepsy with the HLA system in Chinese narcoleptic patients.
METHODS: To explore the role of HLA-DRB genes in the development of narcolepsy, we studied 10 narcoleptic patients and 50 race matched controls in whom HLA-DR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP).
RESULTS: All narcoleptic patients were found to be of DRB1 * 1501 and DRB5 * 0101 genotype.
CONCLUSION: These results indicate that HLA-DRB1 * 1501 is a better primary candidate susceptibility gene for narcolepsy in Chinese.
METHODS: To explore the role of HLA-DRB genes in the development of narcolepsy, we studied 10 narcoleptic patients and 50 race matched controls in whom HLA-DR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP).
RESULTS: All narcoleptic patients were found to be of DRB1 * 1501 and DRB5 * 0101 genotype.
CONCLUSION: These results indicate that HLA-DRB1 * 1501 is a better primary candidate susceptibility gene for narcolepsy in Chinese.