Natural product research · 2024
Analysing chemical composition and antimicrobial activity of geopropolis from Melipona scutellaris: HPLC-DAD and in vitro/in silico investigations.
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de Souza Jéssica Lima, Ferreira Adrianne Bastos, Paulo Elinalva Maciel, Alves Clayton Queiroz, de Carvalho Carlos Alfredo Lopes, Dias Fábio de Souza, de Freitas Santos Junior Anibal, Brandão Hugo Neves, de Freitas Humberto Fonseca
Аннотация
This study evaluated the chemical profile, antimicrobial activity, and the presence of potentially toxic elements in geopropolis extracts produced by Melipona scutellaris in the Recôncavo region of Bahia, Brazil. It was found that the major chemical compounds belong to the class of phenolic compounds, with emphasis on the presence of gallic acid. In this study, no potentially toxic elements were found in the analysed geopropolis. Regarding the antimicrobial potential, gram-positive bacteria were susceptible to the action of geopropolis extract at concentrations of 0.25 to 2.5 mg.mL-1, highlighting its microbiological activity against Streptococcus mitis (ATCC 00456) and Candida albicans (CCMB 251). Thus, this geopropolis extract can be used as a bacteriostatic rather than a bactericide. Our results suggest the potential for the economic and therapeutic use of M. scutellaris geopropolis, adding value to one of the meliponiculture products.