The Angle orthodontist · 2014
Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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de Albuquerque Taddei Silvana Rodrigues, Madeira Mila Fernandes Moreira, de Abreu Lima Izabella Lucas, Queiroz-Junior Celso Martins, Moura Adriana Pedrosa, Oliveira Dauro Douglas, Andrade Ildeu, da Glória Souza Danielle, Teixeira Mauro Martins, da Silva Tarcília Aparecida
Аннотация
OBJECTIVE: To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice.
MATERIALS AND METHODS: Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
RESULTS: The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
CONCLUSIONS: These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.
MATERIALS AND METHODS: Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
RESULTS: The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
CONCLUSIONS: These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.
Предметные рубрики MeSH
Acid PhosphataseAggregatibacter actinomycetemcomitansAlveolar Bone LossAlveolar ProcessAnimalsBone Density Conservation AgentsCalcitriolCalciumCalcium CarbonateCalcium, DietaryCell CountDietary SupplementsDisease Models, AnimalIsoenzymesMaleMiceMice, Inbred BALB CMice, Inbred C57BLOsteoclastsPasteurellaceae InfectionsPeriodontal DiseasesRhodophytaTartrate-Resistant Acid PhosphataseTooth Movement TechniquesTumor Necrosis Factor-alpha