Efficacy of Antenatal Treatment Using IVIG and Steroids in Managing Subsequent Pregnancy Following a Case of Neonatal Alloimmune Thrombocytopenia in Sibling.

Neonatal alloimmune thrombocytopenia (NAIT) can present as severe thrombocytopenia in an otherwise healthy neonate and may lead to serious bleeding, intracranial hemorrhage, and even death. This report presents two siblings affected by NAIT. The first sibling was diagnosed when the infant presented after birth with petechial hemorrhages and a profoundly low platelet count. During the subsequent pregnancy, the mother was treated with a protocol of IVIG and steroid. This resulted in a higher platelet count at birth in the second sibling, although still severely thrombocytopenic, without physical signs or symptoms of thrombocytopenia. In this case, the infant responded rapidly to an antigen-matched platelet transfusion. This case series calls attention to the importance of close follow-up and optimum management of NAIT.