Designing suture-proof cell-attachable copolymer-mediated and curcumin- β-cyclodextrin inclusion complex loaded aliphatic polyester-based electrospun antibacterial constructs.

The paper demonstrates curcumin/β-cyclodextrin-based inclusion complex (IC) loaded polyvinyl alcohol (PVA) dip-coated and copolymer-compatibilized polylactic acid (PLA)/poly(ε-caprolactone) (PCL) blend-based electrospun mats (EMs) as antibacterial, and suture-resistant constructs, to overcome the present challenges in developing structurally-stable, biocompatible, pliable, and stand-alone multifunctional-biomedical-devices. The thermal, microstructural, and viscoelastic characterization confirmed the presence of H-bonding interactions between IC and PVA moieties and between IC incorporated PVA matrix with the copolymer-mediated nanotextured PLA/PCL blend-based EMs. IC release and surface PVA erosion induced a decrease in modulus (>4-fold) and strength (>2-fold) of constructs (post-release). Mechanistically new and architectural-framework-defined PVA-gelation induced bi-axially diverted suture-failure (post-release) and resulted in a significant enhancement in suture-retention-strength (>3-fold), energy (>5-fold), and displacement (>2-fold) for ~20 wt% IC-loaded-PVA-coated EM-constructs. The fabricated EM-constructs exhibited improvement in surface-hydrophilicity (contact angle ~45°), surface nano-roughness (~ 600 nm), surface area (~34 m2/g), pore volume (~3.6 × 10-2 cc/g), IC release efficacy (~20 % burst release), antibacterial activity (adherent bacteria <10 %) against E. coli and S. aureus, and L929 fibroblast-cell-viability (~135 %), which varied as a function of IC-content in the PVA matrix. Our study conceptually establishes a novel and efficient technique for designing antibacterial, suture-resistant engineered-EM-constructs with tunable properties for their potential use in wound-dressings, periodontal-membranes, drug-delivery, and regenerative-systems.