Gan to kagaku ryoho. Cancer & chemotherapy · 2023
[A Case of Appendiceal Carcinoma with BRAF V600E Mutation and Microsatellite Instability-High].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Inagaki Tatsuki, Tajima Yosuke, Shimada Yoshifumi, Nakano Mae, Nakano Masato, Abe Kaoru, Yamai Daisuke, Ozeki Hikaru, Muneoka Yusuke, Ishikawa Hirosuke, Kano Yosuke, Ichikawa Hiroshi, Takizawa Kazuyasu, Sakata Jun, Wakai Toshifumi
Аннотация
A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma. Computed tomography showed an appendiceal mass of 11.8×6.7 cm in size involving the cecum and terminal ileum without any distant metastatic findings. Ileocecal resection with regional lymph node dissection to the root of the ileocolonic artery was performed. Histopathological examination of the specimen revealed appendiceal adenocarcinoma. Molecular subtype of the tumor was BRAF V600E mutation and microsatellite instability-high(MSI-H). The pathological stage was pT4bpN1bcM0, pStage ⅢC. She received 8 courses of CapeOX as adjuvant chemotherapy and no recurrence was noted 12 months following the surgery. The establishment of standard treatment strategies including surgery, chemotherapy, and immunotherapy for carcinoma of the appendix with BRAF V600E mutation and/or MSI-H is needed.