Neurology. Clinical practice · 2023
Characterization of Migraine in Children and Adolescents With Generalized Joint Hypermobility: A Case-Control Study.
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Ghosh Ankita, Horn Paul S, Kabbouche Samaha Marielle, Kacperski Joanne, LeCates Susan L, White Shannon, Powers Scott W, Hershey Andrew D
Аннотация
BACKGROUND AND OBJECTIVES: The prevalence of generalized joint hypermobility (GJH) is 5-65% in children and adolescents. The hypothesis of this study was to see whether there is an association between headache characteristics and GJH in children and adolescents with migraine.
METHODS: We performed a primary retrospective case-control analysis of an established database of patients with headache aged 5-17 years.
RESULTS: We included 5435 participants. Approximately 31.6% of participants (1,719/5,435) were diagnosed with GJH (Beighton score ≥ 6). Nausea (73.1% vs 67.5%, χ2 with 1 degree of freedom = 17.0, p < 0.0001), phonophobia (87.3% vs 78.8%, χ2 with 1 degree of freedom = 18.0, p < 0.0001), and the PedMIDAS score (48.2 ± 52.5, 95% CI 45.7-50.6 vs 41.6 ± 51.2, 95% CI 40.0-43.3, effect size = 0.13, p < 0.0001) were noted to be more severe in participants with GJH than those without GJH.
DISCUSSION: Youths with GJH and migraine were noted to have more severe migraine characteristics.
METHODS: We performed a primary retrospective case-control analysis of an established database of patients with headache aged 5-17 years.
RESULTS: We included 5435 participants. Approximately 31.6% of participants (1,719/5,435) were diagnosed with GJH (Beighton score ≥ 6). Nausea (73.1% vs 67.5%, χ2 with 1 degree of freedom = 17.0, p < 0.0001), phonophobia (87.3% vs 78.8%, χ2 with 1 degree of freedom = 18.0, p < 0.0001), and the PedMIDAS score (48.2 ± 52.5, 95% CI 45.7-50.6 vs 41.6 ± 51.2, 95% CI 40.0-43.3, effect size = 0.13, p < 0.0001) were noted to be more severe in participants with GJH than those without GJH.
DISCUSSION: Youths with GJH and migraine were noted to have more severe migraine characteristics.