The Thoracic and cardiovascular surgeon · 2006
Effects of glucose-insulin-potassium solution on cardiac cytokines and enzymes.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Celkan M A, Kazaz H, Daglar B, Celik A, Koruk S, Kocoglu H
Аннотация
OBJECTIVE: The aim of this study was to assess the effects of glucose-insulin-potassium (GIK) solution on intraoperative cardiac cytokines and cardiac enzymes in coronary artery bypass surgery patients.
METHODS: The study group consisted of 49 patients with unstable angina who required urgent CABG. Patients were randomized to a GIK (n = 25) or a non-GIK (n = 24) group. The GIK group received 500 ml of 30 % dextrose solution, containing 100 IU insulin and 80 mEq of potassium, at a rate of 1 ml x kg (-1) x h (-1). The control group received an equivalent rate of 5 % dextrose. Serum cytokine levels were measured in blood samples obtained from coronary sinus blood samples. Cardiac enzymes such as creatinin kinase (CK), myocardial band of creatinin kinase (CK-MB) and Troponin-T were measured immediately after operation and at 6, 24 and 48 hours after operation.
RESULTS: No patient in the two groups developed ECG or enzyme changes after surgery suggestive of acute myocardial infarction and myocyte damage. Interleukin-10 concentrations were greater in the GIK group (31.10 +/- 3.36) than in the non-GIK group (19.10 +/- 4.32) ( P < 0.05).
CONCLUSION: We conclude that a GIK solution increases the serum cardioprotective interleukin-10 concentrations in CABG patients with unstable angina pectoris. We found no significant difference in any of the other parameters respecting myocyte damage.
METHODS: The study group consisted of 49 patients with unstable angina who required urgent CABG. Patients were randomized to a GIK (n = 25) or a non-GIK (n = 24) group. The GIK group received 500 ml of 30 % dextrose solution, containing 100 IU insulin and 80 mEq of potassium, at a rate of 1 ml x kg (-1) x h (-1). The control group received an equivalent rate of 5 % dextrose. Serum cytokine levels were measured in blood samples obtained from coronary sinus blood samples. Cardiac enzymes such as creatinin kinase (CK), myocardial band of creatinin kinase (CK-MB) and Troponin-T were measured immediately after operation and at 6, 24 and 48 hours after operation.
RESULTS: No patient in the two groups developed ECG or enzyme changes after surgery suggestive of acute myocardial infarction and myocyte damage. Interleukin-10 concentrations were greater in the GIK group (31.10 +/- 3.36) than in the non-GIK group (19.10 +/- 4.32) ( P < 0.05).
CONCLUSION: We conclude that a GIK solution increases the serum cardioprotective interleukin-10 concentrations in CABG patients with unstable angina pectoris. We found no significant difference in any of the other parameters respecting myocyte damage.