[Surgery of the hypophyseo-hypothalamic lesions and the circadian rhythm of ADH secretion].

Various clinical disorders of water and electrolytes metabolism were reported in relation to decrease or increase of the plasma anti-diuretic hormone (ADH), however, the estimated ADH value was not infrequently found inconsistent with clinical features. In order to determine the influence from surgical intervention to the hypophyseo-hypothalamic system, continuous estimation of the urinary secretion and specific gravity was performed with computerized analyzer, and it was found that there were at least 5 patterns of postoperative change in rhythmicity of ADH secretion. Most interesting finding was that the ADH was discharged in phasic pattern and irregularly intermingled oligo- and polyuric phases were observed quite in early stage of postoperative observation. Forty cases were examined and this method of examination was found useful in the prognostic view point for the postoperative water and electrolytes disorders.