African journal of infectious diseases · 2025
ANTI-INFLAMMATORY AND METABOLIC EFFECTS OF COFFEA CANEPHORA EXTRACT IN DIABETIC RATS: INSIGHTS FROM TNF-Α REDUCTION AND INSULIN SENSITIVITY INDICES.
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Siahaan Jekson Martiar, Anto Endy Juli, Fauzi Tengku Muhammad, Pasaribu Sumihar Mr, Ginting Hana Isal Salina, Sitorus Friska Ernita, Hariati Hariati, Fahdi Firdaus, Ariani Peny, Sujianto Untung, Simanullang Rostime Hermayerni, Sinurat Suryati, Sinatra Jadeny, Lim Hadyanto
Аннотация
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by Insulin resistance, hyperglycemia, and systemic inflammation. Coffea canephora var. robusta contains bioactive compounds with potential antihyperglycemic and anti-inflammatory effects. This study aimed to evaluate the metabolic and inflammatory effects of its ethanolic extract in a rat model of T2DM.
MATERIALS AND METHODS: Forty-four male Wistar rats were randomized into 11 groups, including normal, diabetic controls, and treatment groups receiving ethanolic or ethyl acetate extracts (100-400 mg/kgBW). T2DM was induced using a high-fat diet and streptozotocin ± nicotinamide. Outcomes measured were fasting blood glucose (FBG), glucose-lowering percentage (%GL), fasting insulin resistance index (FIRI), quantitative insulin sensitivity check index (QUICKI), and TNF-α levels.
RESULTS: The 400 mg/kgBW ethanolic extract group showed a significant reduction in FBG (p = 0.017), percentage of glucose lowering (p = 0.000), TNF-α levels (p = 0.000), and body weight (p = 0.000) compared to diabetic controls, indicating improved metabolic regulation.
CONCLUSION: The ethanolic extract of C. canephora improves glycemic control, enhances insulin sensitivity, and reduces inflammation in T2DM rats, supporting its potential for future clinical validation.
MATERIALS AND METHODS: Forty-four male Wistar rats were randomized into 11 groups, including normal, diabetic controls, and treatment groups receiving ethanolic or ethyl acetate extracts (100-400 mg/kgBW). T2DM was induced using a high-fat diet and streptozotocin ± nicotinamide. Outcomes measured were fasting blood glucose (FBG), glucose-lowering percentage (%GL), fasting insulin resistance index (FIRI), quantitative insulin sensitivity check index (QUICKI), and TNF-α levels.
RESULTS: The 400 mg/kgBW ethanolic extract group showed a significant reduction in FBG (p = 0.017), percentage of glucose lowering (p = 0.000), TNF-α levels (p = 0.000), and body weight (p = 0.000) compared to diabetic controls, indicating improved metabolic regulation.
CONCLUSION: The ethanolic extract of C. canephora improves glycemic control, enhances insulin sensitivity, and reduces inflammation in T2DM rats, supporting its potential for future clinical validation.