PLoS genetics · 2010
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Pillas Demetris, Hoggart Clive J, Evans David M, O'Reilly Paul F, Sipilä Kirsi, Lähdesmäki Raija, Millwood Iona Y, Kaakinen Marika, Netuveli Gopalakrishnan, Blane David, Charoen Pimphen, Sovio Ulla, Pouta Anneli, Freimer Nelson, Hartikainen Anna-Liisa, Laitinen Jaana, Vaara Sarianna, Glaser Beate, Crawford Peter, Timpson Nicholas J, Ring Susan M, Deng Guohong, Zhang Weihua, McCarthy Mark I, Deloukas Panos, Peltonen Leena, Elliott Paul, Coin Lachlan J M, Smith George Davey, Jarvelin Marjo-Riitta
Аннотация
Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.