Clinical nutrition (Edinburgh, Scotland) · 2025
Longitudinal associations of serum fatty acids derived from dairy consumption with early prediabetes phenotypes: The PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yehia Nagam A, Santaren Ingrid, Johnston Luke W, Sievenpiper John L, Giacca Adria, Retnakaran Ravi, Harris Stewart B, Bazinet Richard P, Hanley Anthony J
Аннотация
BACKGROUND: Dairy derived saturated and trans fatty acids may contribute to inverse associations of dairy intake with type 2 diabetes mellitus (T2DM) risk. Longitudinal studies examining this association are limited. This study investigated longitudinal associations of 15:0, trans-16:1n9, trans-18:1n11, and c9, trans-11 conjugated linoleic acid (CLA) in four serum fractions with insulin sensitivity, beta cell function and glucose concentrations.
METHODS: Data were obtained from the Prospective Metabolism Islet Cell Evaluation (PROMISE) cohort (n = 418) from 4 separate evaluations over 9 years. Insulin sensitivity was assessed using Matsuda's insulin sensitivity index (ISI) and the homeostasis model assessment of insulin sensitivity (HOMA2_S). Beta cell function was determined using the insulinogenic index divided by HOMA insulin resistance (IGI/IR) and the Insulin Secretion-Sensitivity Index-2 (ISSI-2). Baseline serum fatty acids (mol%) were analyzed using gas chromatography flame-ionization detection. Longitudinal associations were analyzed using covariate-adjusted generalized estimating equations with false discovery adjusted P values.
RESULTS: In the phospholipid (PL) pool, 15:0 was positively associated with logISSI2 (β = 6.54, CI: [2.84, 10.37], p < 0.01) and logIGI/IR (β = 14.75, CI: [6.92, 23.15], p < 0.01), and significantly inversely associated with logGlucose120 (β = -3.45, CI: [-5.63, -1.22], p < 0.05) and logGlucose Area Under the Curve (AUC) (β = -2.84, CI: [-4.38, -1.40], p < 0.01). Trans-16:1n9was significantly associated with logISI (β = 8.08, CI: [2.06, 14.45], p < 0.05) and inversely associated with logGlucose120 (β = -3.11, CI: [-5.50, -0.66], p < 0.05) and logGlucoseAUC (β = -2.16, CI: [-3.75, -0.55], p < 0.05).
CONCLUSIONS: Our findings extend the literature on the potential role of dairy derived saturated and trans conjugate fatty acids in cardiometabolic phenotypes underlying T2DM, specifically in the PL fraction.
METHODS: Data were obtained from the Prospective Metabolism Islet Cell Evaluation (PROMISE) cohort (n = 418) from 4 separate evaluations over 9 years. Insulin sensitivity was assessed using Matsuda's insulin sensitivity index (ISI) and the homeostasis model assessment of insulin sensitivity (HOMA2_S). Beta cell function was determined using the insulinogenic index divided by HOMA insulin resistance (IGI/IR) and the Insulin Secretion-Sensitivity Index-2 (ISSI-2). Baseline serum fatty acids (mol%) were analyzed using gas chromatography flame-ionization detection. Longitudinal associations were analyzed using covariate-adjusted generalized estimating equations with false discovery adjusted P values.
RESULTS: In the phospholipid (PL) pool, 15:0 was positively associated with logISSI2 (β = 6.54, CI: [2.84, 10.37], p < 0.01) and logIGI/IR (β = 14.75, CI: [6.92, 23.15], p < 0.01), and significantly inversely associated with logGlucose120 (β = -3.45, CI: [-5.63, -1.22], p < 0.05) and logGlucose Area Under the Curve (AUC) (β = -2.84, CI: [-4.38, -1.40], p < 0.01). Trans-16:1n9was significantly associated with logISI (β = 8.08, CI: [2.06, 14.45], p < 0.05) and inversely associated with logGlucose120 (β = -3.11, CI: [-5.50, -0.66], p < 0.05) and logGlucoseAUC (β = -2.16, CI: [-3.75, -0.55], p < 0.05).
CONCLUSIONS: Our findings extend the literature on the potential role of dairy derived saturated and trans conjugate fatty acids in cardiometabolic phenotypes underlying T2DM, specifically in the PL fraction.