Nature communications · 2016
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Lorenzi Hernan, Khan Asis, Behnke Michael S, Namasivayam Sivaranjani, Swapna Lakshmipuram S, Hadjithomas Michalis, Karamycheva Svetlana, Pinney Deborah, Brunk Brian P, Ajioka James W, Ajzenberg Daniel, Boothroyd John C, Boyle Jon P, Dardé Marie L, Diaz-Miranda Maria A, Dubey Jitender P, Fritz Heather M, Gennari Solange M, Gregory Brian D, Kim Kami, Saeij Jeroen P J, Su Chunlei, White Michael W, Zhu Xing-Quan, Howe Daniel K, Rosenthal Benjamin M, Grigg Michael E, Parkinson John, Liu Liang, Kissinger Jessica C, Roos David S, Sibley L David
Аннотация
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.