Parkinsonism & related disorders · 2025
Amygdala neurodegeneration differentiates brain-first and body-first Parkinson's disease: An MRI study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schröter Nils, Matinpalo Laura, Hosp Jonas A, Reisert Marco, Philipsen Lea, Jost Wolfgang H, Wiendl Heinz, Urbach Horst, Rijntjes Michel, Rau Alexander
Аннотация
BACKGROUND: Two distinct patterns of alpha-synuclein spread in Parkinson's disease were proposed with a body-first and a brain-first subtype. The body-first subtype originates in the periphery, while the brain-first subtype initiates in the central nervous system, notably affecting the amygdala.
OBJECTIVES: This retrospective cross-sectional study compared the integrity of the substantia nigra and amygdala between body-first and brain-first Parkinson's disease subtypes.
METHODS: We analyzed data from 30 Parkinson's disease patients, classified into body-first (n = 21) and brain-first (n = 9) subtypes based on REM sleep behavior disorder history. Microstructural integrity was assessed using diffusion microstructure MRI.
RESULTS: No significant differences were found in the substantia nigra between subtypes. However, amygdala degeneration was significantly pronounced in the "brain-first" compared to the "body-first" group reflected by increased free interstitial fluid (p = 0.02, Cohen's d = -1.22).
CONCLUSIONS: The degeneration of amygdala is distinctively pronounced in "brain-first" Parkinson's disease, supporting differential disease progression patterns between subtypes.
OBJECTIVES: This retrospective cross-sectional study compared the integrity of the substantia nigra and amygdala between body-first and brain-first Parkinson's disease subtypes.
METHODS: We analyzed data from 30 Parkinson's disease patients, classified into body-first (n = 21) and brain-first (n = 9) subtypes based on REM sleep behavior disorder history. Microstructural integrity was assessed using diffusion microstructure MRI.
RESULTS: No significant differences were found in the substantia nigra between subtypes. However, amygdala degeneration was significantly pronounced in the "brain-first" compared to the "body-first" group reflected by increased free interstitial fluid (p = 0.02, Cohen's d = -1.22).
CONCLUSIONS: The degeneration of amygdala is distinctively pronounced in "brain-first" Parkinson's disease, supporting differential disease progression patterns between subtypes.