Experimental Therapeutics in Parkinson's Disease: A Review.

The prevalence and burden of Parkinson's disease (PD) is rising. Motor symptoms are primarily treated with dopamine replacement, although with limitations and complications over time. Advances in PD research include new drug candidates and innovative repurposing of existing drugs targeting various molecular mechanisms. Several agents are under Food and Drug Administration review, highlighting the dynamic progress in the field. This review summarizes the latest experimental therapies for PD, including both motor and nonmotor symptom treatments. A total of 147 studies were included, examining new dopaminergic and nondopaminergic therapies, innovative drug formulations, and approaches to managing motor complications and nonmotor symptoms.