Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC).
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Gillessen Silke, Turco Fabio, Davis Ian D, Efstathiou Jason A, Fizazi Karim, James Nicholas D, Shore Neal, Small Eric, Smith Matthew, Sweeney Christopher J, Tombal Bertrand, Zilli Thomas, Agarwal Neeraj, Antonarakis Emmanuel S, Aparicio Ana, Armstrong Andrew J, Bastos Diogo Assed, Attard Gerhardt, Axcrona Karol, Ayadi Mouna, Beltran Himisha, Bjartell Anders, Blanchard Pierre, Bourlon Maria T, Briganti Alberto, Bulbul Muhammad, Buttigliero Consuelo, Caffo Orazio, Castellano Daniel, Castro Elena, Cheng Heather H, Chi Kim N, Clarke Caroline S, Clarke Noel, de Bono Johann S, De Santis Maria, Duran Ignacio, Efstathiou Eleni, Ekeke Onyeanunam N, El Nahas Tamer I H, Emmett Louise, Fanti Stefano, Fatiregun Omolara A, Feng Felix Y, Fong Peter C C, Fonteyne Valerie, Fossati Nicola, George Daniel J, Gleave Martin E, Gravis Gwenaelle, Halabi Susan, Heinrich Daniel, Herrmann Ken, Hofman Michael S, Hope Thomas A, Horvath Lisa G, Hussain Maha H A, Jereczek-Fossa Barbara Alicja, Jones Robert J, Joshua Anthony M, Kanesvaran Ravindren, Keizman Daniel, Khauli Raja B, Kramer Gero, Loeb Stacy, Mahal Brandon A, Maluf Fernando C, Mateo Joaquin, Matheson David, Matikainen Mika P, McDermott Ray, McKay Rana R, Mehra Niven, Merseburger Axel S, Morgans Alicia K, Morris Michael J, Mrabti Hind, Mukherji Deborah, Murphy Declan G, Murthy Vedang, Mutambirwa Shingai B A, Nguyen Paul L, Oh William K, Ost Piet, O'Sullivan Joe M, Padhani Anwar R, Parker Chris, Poon Darren M C, Pritchard Colin C, Rabah Danny M, Rathkopf Dana, Reiter Robert E, Renard-Penna Raphaele, Ryan Charles J, Saad Fred, Sade Juan Pablo, Sandhu Shahneen, Sartor Oliver A, Schaeffer Edward, Scher Howard I, Sharifi Nima, Skoneczna Iwona A, Soule Howard R, Spratt Daniel E, Srinivas Sandy, Sternberg Cora N, Suzuki Hiroyoshi, Taplin Mary-Ellen, Thellenberg-Karlsson Camilla, Tilki Derya, Türkeri Levent N, Uemura Hiroji, Ürün Yüksel, Vale Claire L, Vapiwala Neha, Walz Jochen, Yamoah Kosj, Ye Dingwei, Yu Evan Y, Zapatero Almudena, Omlin Aurelius
Аннотация
METHODS: Before the conference, a panel of 120 international PC experts used a modified Delphi process to develop 183 multiple-choice consensus questions on eight different topics. Before the conference, these questions were administered via a web-based survey to the voting panel members ("panellists").
KEY FINDINGS AND LIMITATIONS: Consensus was a priori defined as ≥75% agreement, with strong consensus defined as ≥90% agreement. The voting results show varying degrees of consensus, as discussed in this article and detailed in the Supplementary material. These findings do not include a formal literature review or meta-analysis.
CONCLUSIONS AND CLINICAL IMPLICATIONS: The voting results can help physicians and patients navigate controversial areas of clinical management for which high-level evidence is scant or conflicting. The findings can also help funders and policymakers in prioritising areas for future research. Diagnostic and treatment decisions should always be individualised on the basis of patient and cancer characteristics, and should incorporate current and emerging clinical evidence, guidelines, and logistic and economic factors. Enrolment in clinical trials is always strongly encouraged. Importantly, APCCC 2024 once again identified important gaps (areas of nonconsensus) that merit evaluation in specifically designed trials.