Actas dermo-sifiliograficas · 2025
[Translated article] Should Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde (Lyral®) Still be Part of the Baseline Series?
СтатьяНазвание и аннотация: Перевод в очереди
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Hernández Fernández C P, Borrego L, Giménez Arnau A M, Sanz Sánchez T, Carrascosa Carrillo J M, Zaragoza Ninet V, Serra Baldrich E, Miquel Miquel F J, Silvestre Salvador J F, Córdoba Guijarro S, Sánchez Gilo A, Mercader García P, Navarro Triviño F, Tous Romero F, Rodríguez Serna M, Melé Ninot G, Ruiz González I, Gómez de la Fuente E, Pastor Nieto M A, Sánchez-Pedreño Guillén P, Sánchez Pérez J, Pereyra Rodríguez J J, Gatica Ortega M E, González Pérez R, García Doval I, Gallego Descalzo M A
Аннотация
BACKGROUND AND OBJECTIVES: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC), or Lyral®, is a fragrance marker that is part of the Fragrance Mix II (FM II) and is still patched as an independent allergen within the European and other baseline series despite the European Commission banning its use in cosmetics in 2021. We aimed to study the prevalence of sensitization to the HICC in Spain and its simultaneous positivity with the FM II to determine whether it should be part of the Spanish baseline series.
MATERIAL AND METHOD: We analyzed all consecutive patients simultaneously patch-tested with HICC and FM II within the Spanish Contact Dermatitis Registry (REIDAC) from June 1st, 2018 to December 31st, 2023.
RESULTS: A total of 96 (0.8%) out of 12,029 patients analyzed yielded positive to HICC and 396 (3.3%) to FM II. In 53% and 64% of the patients, respectively, findings were considered currently relevant. A total of 72 out of 96 (75%) HICC positives would be detected if only FM II was patched.
CONCLUSIONS: Prevalence of HICC sensitization in Spain is low and has decreased in recent years. HICC is a prohibited fragrance in cosmetics and FM II detects 3 in 4 sensitized patients. Our results suggest that HICC should remain outside the Spanish baseline series and support its exclusion from the European baseline series.
MATERIAL AND METHOD: We analyzed all consecutive patients simultaneously patch-tested with HICC and FM II within the Spanish Contact Dermatitis Registry (REIDAC) from June 1st, 2018 to December 31st, 2023.
RESULTS: A total of 96 (0.8%) out of 12,029 patients analyzed yielded positive to HICC and 396 (3.3%) to FM II. In 53% and 64% of the patients, respectively, findings were considered currently relevant. A total of 72 out of 96 (75%) HICC positives would be detected if only FM II was patched.
CONCLUSIONS: Prevalence of HICC sensitization in Spain is low and has decreased in recent years. HICC is a prohibited fragrance in cosmetics and FM II detects 3 in 4 sensitized patients. Our results suggest that HICC should remain outside the Spanish baseline series and support its exclusion from the European baseline series.