Enteric nervous system.

PURPOSE OF REVIEW: Enteric neurobiology is a rapidly advancing field of investigation providing insight into the way in which diverse gastrointestinal functions are controlled, coordinated and integrated with central mechanisms important for food intake regulation, illness behaviour and sensory mechanisms. Our aim was to highlight recent advances.

RECENT FINDINGS: With such a large number of studies to choose from and given our emphasis in previous years on developmental aspects, sensory transmission, and neuro-immune interactions, we have focused on two themes. One reflecting the current interest in the way the enteric nervous system is altered in disease and the second covering the enormous interest in the contribution of enteric mechanisms to the control of energy balance.

SUMMARY: The new basic science information gathered during the past year provides insight into pathophysiological processes and will pave the way for improved understanding of both organic and 'functional' gastrointestinal disorders.