A simple method for intragastric administration of powdered materials to rats.

A simple technique was used for administration of powdered material directly into the stomach of rats. A commerically available positive displacement pipetting device was filled by tamping the cannula tip into the powder. The contents of the cannula could then be discharged into the stomach by insertion of the cannula via the esophagus. The device required only minor modifications prior to its use in this manner. The technique provided a means of accurate dosing of insoluble materials and eliminated the difficulties encountered in the oral administration of suspensions.