[Blood concentrations of sulfadimidine after the internal use of depot sulfadimezine granules in sheep].

A granular premixed form, called sulphadimesin-depot-granules, was produced, containing 40% of sulphadimine inserted into a hydrophobic matrix of hydrogeneric sunflower oil. After a single internal insertion into sheep by means of a stomach-tube or of a bottle on an empty stomach in a dose of 0.5 g/kg t, they caused bacteriostatic concentrations in blood plasma during 78 hours, and in a dose of 1.0 g/kg t--during 96 hours, whereas the sulphadimesin in tablets, applied in a dose of 0.2g/kg t, kept up a therapeutic concentration for 24 hours. The duration of the bacteriostatic level of sulphadimesin after the taking of the granules in a dose of 0.5 g/kg t and after the feeding, was 12 hours; after two treatment with a stomach-tube or of a bottle, on an empty stomach, in an initial dose of 1.0 g/kg t and a following one of 0.5 g/kg t, applied after a period of 96 hours--it was 174 hours. No side phenomena were observed, besides a temporary (for 12-24 h) slight slow-down of belly movements. For a prophylactic treatment of sheep it is recommended that the granules should be applied in the fodder and on an empty stomach, in an initial dose of 1.0 g/kg t, and 72 hours later in a dose of 0.5 g/kg t. For a curative treatment an internal insertion is recommended by means of a stomach-tube or of a bottle, on an empty stomach, in the same doses, at an interval of 96 hours.