In vivo activity of an extract of Pavetta owariensis bark on experimental Schistosoma mansoni infection in mice.

Mice were experimentally infected with Schistosoma mansoni. Comparisons were carried out of total body weight, weight of liver, spleen and left lung, number of adult worms and eggs, and size of liver granulomas between an untreated group and a group treated only with an alcoholic extract of Pavetta owariensis. In the treated group, liver granulomas were smaller for both the acute and chronic infections, indicating a modulation of the granulomatous reaction. A reduction of worm burden, especially of male worms was observed after treatment of chronically infected mice with the same extract.