Intensive care medicine · 2006
Incidence and risk factors of device-associated infections and associated mortality at the intensive care in the Dutch surveillance system.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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van der Kooi Tjallie I I, de Boer Annette S, Manniën Judith, Wille Jan C, Beaumont Mariëlle T, Mooi Ben W, van den Hof Susan
Аннотация
OBJECTIVE: To examine the incidence of and risk factors for device-associated infections and associated mortality.
DESIGN AND SETTING: Prospective surveillance-based study in ICUs of 19 hospitals in The Netherlands.
PATIENTS: The study included 2,644 patients without infection at admission during 1997-2000, staying in the ICU for at least 48 h.
MEASUREMENTS AND RESULTS: The occurrence of ventilator-associated pneumonia (VAP), central venous catheter (CVC) related bloodstream infection (CR-BSI), urinary catheter-associated urinary tract infection (CA-UTI) and risk factors was monitored. Of the ventilated patients 19% developed pneumonia (25/1,000 ventilator days); of those with a central line 3% developed CR-BSI (4/1,000 CVC days,) and of catheterized patients 8% developed CA-UTI (9/1,000 catheter days). Longer device use increased the risk for all infections, especially for CR-BSI. Independent risk factors were sex, immunity, acute/elective admission, selective decontamination of the digestive tract, and systemic antibiotics at admission, dependent upon the infection type. Crude mortality significantly differed in patients with and without CR-BSI (31% vs. 20%) and CA-UTI (27% vs. 17%) but not for VAP (26% vs. 23%). Acquiring a device-associated infection was not an independent risk factor for mortality. Being in need of ventilation or a central line, and the duration of this, contributed significantly to mortality, after adjusting for other risk factors.
CONCLUSIONS: Device use was the major risk factor for acquiring VAP, CR-BSI and CA-UTI. Acquiring a device-associated infection was not an independent risk factor for mortality, but device use in itself was.
DESIGN AND SETTING: Prospective surveillance-based study in ICUs of 19 hospitals in The Netherlands.
PATIENTS: The study included 2,644 patients without infection at admission during 1997-2000, staying in the ICU for at least 48 h.
MEASUREMENTS AND RESULTS: The occurrence of ventilator-associated pneumonia (VAP), central venous catheter (CVC) related bloodstream infection (CR-BSI), urinary catheter-associated urinary tract infection (CA-UTI) and risk factors was monitored. Of the ventilated patients 19% developed pneumonia (25/1,000 ventilator days); of those with a central line 3% developed CR-BSI (4/1,000 CVC days,) and of catheterized patients 8% developed CA-UTI (9/1,000 catheter days). Longer device use increased the risk for all infections, especially for CR-BSI. Independent risk factors were sex, immunity, acute/elective admission, selective decontamination of the digestive tract, and systemic antibiotics at admission, dependent upon the infection type. Crude mortality significantly differed in patients with and without CR-BSI (31% vs. 20%) and CA-UTI (27% vs. 17%) but not for VAP (26% vs. 23%). Acquiring a device-associated infection was not an independent risk factor for mortality. Being in need of ventilation or a central line, and the duration of this, contributed significantly to mortality, after adjusting for other risk factors.
CONCLUSIONS: Device use was the major risk factor for acquiring VAP, CR-BSI and CA-UTI. Acquiring a device-associated infection was not an independent risk factor for mortality, but device use in itself was.