Journal of the Endocrine Society · 2018
Feedback on LH in Testosterone-Clamped Men Depends on the Mode of Testosterone Administration and Body Composition.
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Roelfsema Ferdinand, Yang Rebecca J, Liu Peter Y, Takahashi Paul Y, Veldhuis Johannes D
Аннотация
CONTEXT: Quantitative studies of the short-term feedback of testosterone (T) on luteinizing hormone (LH) secretion in healthy men are relatively rare. Such studies require the shutting down of endogenous T secretion and the imposition of experimentally controlled IV T addback.
OBJECTIVE: To evaluate whether pulsatile and continuous T delivery confers equivalent negative feedback on LH secretion.
DESIGN: This was a placebo-controlled, blinded, and prospectively randomized crossover study comprising 16 healthy men [age range 23 to 54 years and a body mass index (BMI) between 22.3 and 34.2 kg/m2]. Subjects received ketoconazole to block endogenous T secretion and received continuous or 90-minute pulses of IV T addback.
SETTING: The study was performed in a Clinical Translational Research Unit.
INTERVENTIONS: Subjects underwent 14 hours of blood sampling at 10-minute intervals, with a bolus IV injection of 33 ng/kg gonadotropin-releasing hormone (GnRH).
MAIN OUTCOME MEASURES: Log-transformed LH and T concentration ratios before and after GnRH administration.
RESULTS: Despite higher T concentrations during pulsatile T feedback, LH concentrations and secretion rates, whether driven by endogenous or exogenous GnRH, were similar to those during continuous T infusion, indicating diminished pulsatile T feedback. Feedback correlated negatively with BMI. Under controlled T feedback, basal but not pulsatile LH secretion correlated negatively with CT-estimated visceral fat mass.
CONCLUSION: Feedback by pulsatile T delivery has diminished inhibitory strength compared with continuous infusion. Feedback is negatively correlated with BMI.
OBJECTIVE: To evaluate whether pulsatile and continuous T delivery confers equivalent negative feedback on LH secretion.
DESIGN: This was a placebo-controlled, blinded, and prospectively randomized crossover study comprising 16 healthy men [age range 23 to 54 years and a body mass index (BMI) between 22.3 and 34.2 kg/m2]. Subjects received ketoconazole to block endogenous T secretion and received continuous or 90-minute pulses of IV T addback.
SETTING: The study was performed in a Clinical Translational Research Unit.
INTERVENTIONS: Subjects underwent 14 hours of blood sampling at 10-minute intervals, with a bolus IV injection of 33 ng/kg gonadotropin-releasing hormone (GnRH).
MAIN OUTCOME MEASURES: Log-transformed LH and T concentration ratios before and after GnRH administration.
RESULTS: Despite higher T concentrations during pulsatile T feedback, LH concentrations and secretion rates, whether driven by endogenous or exogenous GnRH, were similar to those during continuous T infusion, indicating diminished pulsatile T feedback. Feedback correlated negatively with BMI. Under controlled T feedback, basal but not pulsatile LH secretion correlated negatively with CT-estimated visceral fat mass.
CONCLUSION: Feedback by pulsatile T delivery has diminished inhibitory strength compared with continuous infusion. Feedback is negatively correlated with BMI.