Predominantly Nonexudative Nature of Choroidal Neovascularization in Central Serous Chorioretinopathy.

BACKGROUND AND

OBJECTIVE

The aim of this study was to evaluate the characteristics of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSCR).

PATIENTS AND

METHODS

Patients with unilateral CSCR complicated by the double-layer sign were enrolled in this retrospective cohort study. Cases with a neovascular network visible on optical coherence tomography angiography were selected for the analysis.

RESULTS

Eighty-two patients (58.7 ± 10.5 years, 39 women [47.6%]) were included. Among 34 eyes receiving no anti-vascular endothelial growth factor therapy (median follow-up 16.0 [IQR 9.8 to 18.8] months), CNV area changed from 0.62 (0.51 to 1.1) to 0.78 (IQR 0.50 to 1.0) mm2 (P = .2) and vascular density changed from 57.8 ± 11.6 to 55.9 ± 11.1% (P = .58). In multivariable analysis, a negative correlation was found between CNV area and central retinal thickness (P = .03). Nonexudative CNV in fellow eyes was found in 16/82 patients (19.5%).

CONCLUSION

Several morphological and clinical characteristics as well as the stationary character suggest that in this specific subset of neovascular CSCR patients CNV has predominantly nonexudative nature.