Nature communications · 2021
Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhao Xue-Ke, Xing Pengwei, Song Xin, Zhao Miao, Zhao Linxuan, Dang Yonglong, Lei Ling-Ling, Xu Rui-Hua, Han Wen-Li, Wang Pan-Pan, Yang Miao-Miao, Hu Jing-Feng, Zhong Kan, Zhou Fu-You, Han Xue-Na, Meng Chao-Long, Ji Jia-Jia, Chen Xingqi, Wang Li-Dong
Аннотация
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis process and may be induced by accumulated DNA damage due to local dietary habits. We observe diverse correlations between the presence of oncogene focal amplifications and prognosis, where ERBB2 focal amplifications positively correlate with prognosis and EGFR focal amplifications negatively correlate with prognosis. Large-scale ERBB2 immunohistochemistry results from 1668 GCA patients show survival probability of ERBB2 positive patients is lower than that of ERBB2 negative patients when their surviving time is under 2 years, however, the tendency is opposite when their surviving time is longer than 2 years. Our observations indicate that the ERBB2 focal amplifications may represent a good prognostic marker in GCA patients.