Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium.
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Martimianaki Georgia, Bertuccio Paola, Alicandro Gianfranco, Pelucchi Claudio, Bravi Francesca, Carioli Greta, Bonzi Rossella, Rabkin Charles S, Liao Linda M, Sinha Rashmi, Johnson Ken, Hu Jinfu, Palli Domenico, Ferraroni Monica, Lunet Nuno, Morais Samantha, Tsugane Shoichiro, Hidaka Akihisa, Hamada Gerson Shigueaki, López-Carrillo Lizbeth, Hernández-Ramírez Raúl Ulises, Zaridze David, Maximovitch Dmitry, Aragonés Nuria, Martin Vicente, Ward Mary H, Vioque Jesus, Garcia de la Hera Manoli, Zhang Zuo-Feng, Kurtz Robert C, Lagiou Pagona, Lagiou Areti, Trichopoulou Antonia, Karakatsani Anna, Malekzadeh Reza, Camargo M Constanza, Curado Maria Paula, Boccia Stefania, Boffetta Paolo, Negri Eva, La Vecchia Carlo
Аннотация
METHODS: A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer.
RESULTS: Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only.
CONCLUSIONS: These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.