Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society · 2009
[A case of Wegener's granulomatosis with pachymeningitis].
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Hayakawa Mio, Nishijima Masayoshi, Inui Kyoko, Ueji Takashi, Akamatsu Hiroaki, Imahashi Yumiko, Mikawa Tatsuro, Otani Kenichiro, Yagyu Kyoko, Kaji Masahide, Kamimori Takao, Fujiwara Hiroshi
Аннотация
A 49-year-old man was admitted to our hospital because of headache, rhinorrhea, and general fatigue. Chest CT revealed some lung nodules bilaterally, and laboratory data were positive for C-ANCA. Brain MRI revealed the findings of pachymeningitis. Wegener's granulomatosis (WG) was diagnosed by the pathological findings of his paranasal sinuses and kidneys. Most of his symptoms remarkably improved with oral corticosteroids and cyclophosphamide. A MEDLINE search about WG with pachymeningitis obtained only 15 cases previously reported in Japan. Considering those reports about WG with pachymeningitis in both Japan and overseas, in some cases pachymeningitis preceded WG, and relatively more cases than normal WG were negative for C-ANCA, furthermore the pathological findings of pachymeningitis were mainly necrotizing granuloma. Therefore pachymeningitis with WG might be mainly composed of granuloma rather than angitis and which might be a expansion of granulomatous inflammation of upper respiratory tract.