Anticancer research · 2016
Long-term Survival After Surgical Treatment of Renal Cell Carcinoma Metastasis Within the Pancreas.
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Fikatas Panagiotis, Klein Fritz, Andreou Andreas, Schmuck Rosa Bianca, Pratschke Johann, Bahra Marcus
Аннотация
BACKGROUND: The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear.
PATIENTS AND METHODS: In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.
RESULTS: Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.
CONCLUSION: The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.
PATIENTS AND METHODS: In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.
RESULTS: Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.
CONCLUSION: The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.