Long-term Survival After Surgical Treatment of Renal Cell Carcinoma Metastasis Within the Pancreas.

BACKGROUND

The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear.

PATIENTS AND

METHODS

In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.

RESULTS

Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.

CONCLUSION

The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.