Total Pancreatectomy With Islet Autotransplantation for Chronic Pancreatitis in Adults: A Systematic Review.

OBJECTIVES

Chronic pancreatitis (CP) is a painful disease that can be refractory to multiple medical, endoscopic, and surgical interventions. Total pancreatectomy with islet autotransplantation (TPIAT) is a procedure that may be used to manage CP while potentially preserving endocrine pancreatic function. This study aims to ascertain the quality of life (QoL) and pain outcomes among CP patients after TPIAT through a systematic review of published literature.

MATERIALS AND

METHODS

A total of 22,691 studies published before May 2024 investigating TPIAT were collected from Scopus, Embase, Central, and PubMed databases. Title/abstract screening and full-text extraction were performed through a blinded, double review using Covidence; study quality was assessed using the MINORS criteria. Studies assessing adult patients undergoing TPIAT that reported pain or QoL outcomes using a validated scale were included. This study protocol has been registered to PROSPERO: CRD42024567887.

RESULTS

Twelve studies matched our criteria, with 1333 patients receiving TPIAT for CP. MINORS scoring indicated a low risk of bias. In all, 80% (8/10) of studies reported a significant increase in at least one QoL outcome after TPIAT and 83% (5/6) reported a significant decrease in pain.

CONCLUSION

TPIAT improves QoL and pain outcomes in CP patients. Future studies should focus on identifying predictors of successful outcomes and exploring the impact of TPIAT on specific patient subgroups.