Diabetes · 2025
Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Wasserfall Clive H, Forsmark Chris E, Li Shuang, Li Liang, Hart Phil A, Goodarzi Mark O, Kudva Yogish C, Bellin Melena D, Yadav Dhiraj, Conwell Darwin L, Serrano Jose, Andersen Dana K, Fisher William, Casu Anna, Cusi Ken, Hughes Steven J, Fogel Evan, Park Walter, Van Den Eeden Stephen K, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
Аннотация
Type 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.