Unilateral neck exploration for primary hyperparathyroidism.

Focused unilateral cervical exploration is a controversial alternative to conventional bilateral neck exploration for primary hyperparathyroidism (HPT) due to solitary adenoma. Development of preoperative localization techniques, notably isotope scintigraphy and small-part, real-time ultrasonography, has increased preoperative parathyroid tumor identification. Critics of scan directed unilateral neck exploration argue it may overlook enlarged parathyroid glands on the unexplored side, increasing the incidence of persistent and recurrent hypercalcemia. Our experience of this operation and prolonged follow-up of patients, however, confirm that it does not increase risk of persistent or recurrent HPT if a strict selection protocol is observed. This ensures the confident further development of minimally invasive surgical procedures for HPT based on the principle of a focused exploration following preoperative localization of the parathyroid adenoma.