Breast (Edinburgh, Scotland) · 2016
Rates of major complications during neoadjuvant and adjuvant chemotherapy for early breast cancer: An off study population.
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Redana S, Sharp A, Lote H, Mohammed K, Papadimitraki E, Capelan M, Ring A
Аннотация
OBJECTIVES: To determine the incidence and risk factors for thromboembolic events (TE) and febrile neutropenia (FN) in patients receiving systemic chemotherapy for early breast cancer (EBC).
METHODS: 325 patients received FEC75, FEC100-T or ECaP for EBC in 2013.
RESULTS: TE occurred in 7.4% and FN in 19.1% of patients. Risk factors for TE were: central venous catheter (p = 0.011). Risk factors for FN were: FEC100-T treatment versus FEC75 and ECaP (p ≤ 0.001); lower pre-treatment neutrophil count (p = 0.009) and poorer performance status (p = 0.012). Two patients died from treatment-related toxicities.
CONCLUSION: In real-world experience, the majority of patients completed adequate treatment, despite significant complications.
METHODS: 325 patients received FEC75, FEC100-T or ECaP for EBC in 2013.
RESULTS: TE occurred in 7.4% and FN in 19.1% of patients. Risk factors for TE were: central venous catheter (p = 0.011). Risk factors for FN were: FEC100-T treatment versus FEC75 and ECaP (p ≤ 0.001); lower pre-treatment neutrophil count (p = 0.009) and poorer performance status (p = 0.012). Two patients died from treatment-related toxicities.
CONCLUSION: In real-world experience, the majority of patients completed adequate treatment, despite significant complications.
Предметные рубрики MeSH
Acute Coronary SyndromeAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularChemotherapy, AdjuvantChemotherapy-Induced Febrile NeutropeniaCyclophosphamideDocetaxelDose-Response Relationship, DrugEpirubicinFemaleFluorouracilHumansIncidenceMastectomyMastectomy, SegmentalMiddle AgedNeoadjuvant TherapyNeoplasm StagingPaclitaxelPulmonary EmbolismRetrospective StudiesRisk FactorsSentinel Lymph Node BiopsyStrokeTaxoidsThromboembolismVenous Thrombosis