Bone strength in primary hyperparathyroidism.

In primary hyperparathyroidism, as is the case for any metabolic bone disease like osteoporosis, bone strength is a function of many variables. In addition to bone density, considerations of bone size, microarchitecture, and dynamic variables related to the evolution of the disease are all likely to influence bone strength. With greater tools to investigate these points and with newly identified cohorts of this disease, some of whom are presenting with the earliest manifestations of abnormal parathyroid function, it is expected that fresh insights will emerge. Greater knowledge of the disease should help in understanding anabolic aspects of PTH when it is used as a treatment for osteoporosis.