Journal of drugs in dermatology : JDD · 2025
Retrospective Review of Dermal Safety Studies of Organic Sunscreens.
СтатьяНазвание и аннотация: Перевод в очереди
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Wilson Leigh T, Chu Christopher, Wang Steven Q, Amponin Regine, Williams Joshua D, Southall Michael D, Ejaz Sadaff
Аннотация
BACKGROUND: Sunscreens can reduce skin cancer and sunburn. Recent studies on dermal penetration have raised concerns about the safety of sunscreens with organic ultraviolet (UV) filters.
OBJECTIVE: The aim of the retrospective study was to assess the dermal safety of chemical sunscreens containing the chemical filters avobenzone, octocrylene, homosalate, and octisalate.
METHOD: A retrospective assessment was conducted of clinical results on sunscreen products of human repeat irritation patch test, cumulative irritation, photo allergy, and photo toxicity.
RESULTS: An analysis of human repeat irritation patch test results involving 38,950 subjects demonstrated that 99.5% of participants experienced no sensitization. Seven participants exhibited a reaction, which was attributed to the preservative rather than the UV filters. Cumulative irritation results in 4,715 subjects showed that 97.8% of participants had no visible irritation, and 29 subjects showed the lowest irritation grade, representing a barely perceivable erythema. No photo-allergy or photo-toxicity reactions were observed.
CONCLUSION: The findings show no to minimal risks of dermal irritation, sensitization, photo-allergy, and photo-irritation, reinforcing the safety profile of these sunscreens. This evidence is valuable in reassuring the public about the strong safety record of organic sunscreens.
OBJECTIVE: The aim of the retrospective study was to assess the dermal safety of chemical sunscreens containing the chemical filters avobenzone, octocrylene, homosalate, and octisalate.
METHOD: A retrospective assessment was conducted of clinical results on sunscreen products of human repeat irritation patch test, cumulative irritation, photo allergy, and photo toxicity.
RESULTS: An analysis of human repeat irritation patch test results involving 38,950 subjects demonstrated that 99.5% of participants experienced no sensitization. Seven participants exhibited a reaction, which was attributed to the preservative rather than the UV filters. Cumulative irritation results in 4,715 subjects showed that 97.8% of participants had no visible irritation, and 29 subjects showed the lowest irritation grade, representing a barely perceivable erythema. No photo-allergy or photo-toxicity reactions were observed.
CONCLUSION: The findings show no to minimal risks of dermal irritation, sensitization, photo-allergy, and photo-irritation, reinforcing the safety profile of these sunscreens. This evidence is valuable in reassuring the public about the strong safety record of organic sunscreens.