Retina (Philadelphia, Pa.) · 2026
RETINAL ISCHEMIC PERIVASCULAR LESIONS IN THE FELLOW EYES OF PATIENTS WITH CENTRAL RETINAL ARTERY OCCLUSION.
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Karaca Adıyeke Seda, Kutlu Uzakgider Neslişah
Аннотация
PURPOSE: To evaluate the prevalence and characteristics of retinal ischemic perivascular lesions (RIPLs) in the clinically unaffected fellow eyes of patients with unilateral central retinal artery occlusion (CRAO) using spectral domain optical coherence tomography.
METHODS: This retrospective case-control study included 39 fellow eyes of patients with CRAO and 57 age-, sex-, and hypertension-matched healthy controls. Macular spectral domain optical coherence tomography scans were assessed for the presence, number, and morphology of RIPLs, classified as narrow (<300 µ m, peaked apex) or wide (>300 µ m, flattened apex). Between-group comparisons were performed using appropriate parametric/nonparametric tests, and odds ratios were calculated for RIPL presence.
RESULTS: Retinal ischemic perivascular lesions were detected in 29 of 39 eyes (74.4%) in the CRAO fellow-eye group and 14 of 57 eyes (24.6%) in controls ( P < 0.001). The mean number of lesions per eye was significantly higher in the CRAO group (1.36 ± 1.22) than in controls (0.35 ± 0.73; P < 0.001). Among CRAO fellow eyes with RIPLs, five eyes (17.2%) showed wide-type lesions, whereas all lesions in controls were narrow. The odds of RIPL presence were higher in the CRAO group (odds ratio 8.12, 95% confidence interval 3.20-20.57; P < 0.001).
CONCLUSION: Increased RIPL burden in the fellow eyes of patients with CRAO suggests that microstructural retinal changes may be detectable even in eyes without clinically evident arterial occlusion. Further longitudinal, multimodal studies are needed to determine the temporal course and underlying mechanisms.
METHODS: This retrospective case-control study included 39 fellow eyes of patients with CRAO and 57 age-, sex-, and hypertension-matched healthy controls. Macular spectral domain optical coherence tomography scans were assessed for the presence, number, and morphology of RIPLs, classified as narrow (<300 µ m, peaked apex) or wide (>300 µ m, flattened apex). Between-group comparisons were performed using appropriate parametric/nonparametric tests, and odds ratios were calculated for RIPL presence.
RESULTS: Retinal ischemic perivascular lesions were detected in 29 of 39 eyes (74.4%) in the CRAO fellow-eye group and 14 of 57 eyes (24.6%) in controls ( P < 0.001). The mean number of lesions per eye was significantly higher in the CRAO group (1.36 ± 1.22) than in controls (0.35 ± 0.73; P < 0.001). Among CRAO fellow eyes with RIPLs, five eyes (17.2%) showed wide-type lesions, whereas all lesions in controls were narrow. The odds of RIPL presence were higher in the CRAO group (odds ratio 8.12, 95% confidence interval 3.20-20.57; P < 0.001).
CONCLUSION: Increased RIPL burden in the fellow eyes of patients with CRAO suggests that microstructural retinal changes may be detectable even in eyes without clinically evident arterial occlusion. Further longitudinal, multimodal studies are needed to determine the temporal course and underlying mechanisms.