Crohn's & colitis 360 · 2022
Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kawaguchi Takaaki, Fukata Masayuki, Omori Teppei, Kiyohara Hiroki, Sugimoto Shinya, Nanki Kosaku, Sujino Tomohisa, Mikami Yohei, Kanai Takanori
Аннотация
BACKGROUND: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored.
METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted.
RESULTS: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients.
CONCLUSIONS: CNIs may be promising treatment options for refractory intestinal BD.
METHODS: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted.
RESULTS: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients.
CONCLUSIONS: CNIs may be promising treatment options for refractory intestinal BD.