Pediatrics international : official journal of the Japan Pediatric Society · 2016
Elevated serum ghrelin, tumor necrosis factor-α and interleukin-6 in congenital heart disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Dandan, Fang Jian, Wang Ruigeng, Sun Dongming, Xia Kun, Yin Wei, Zhang Sai, Sun Liqun
Аннотация
BACKGROUND: The aim of this study was to investigate the association of congenital heart disease (CHD) with serum ghrelin, tumor necrosis factor-α (TNF-α) and interleukin (IL)-6.
METHOD: Sixty-three children with CHD, hospitalized between January 2012 and September 2014 at Wuhan Women and Children's Health Care Center, were selected as the study group. Additionally, 28 healthy individuals who had physical examinations at this hospital were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum ghrelin, TNF-α and IL-6. SPSS 18.0 and Comprehensive Meta-analysis 2.0 were used for data analysis.
RESULTS: There was significant difference in weight, height and body mass index (BMI; all P < 0.05) but not in age or sex (both P > 0.05) between the cyanotic CHD (CCHD), acyanotic CHD (ACHD) and control groups. On one-way analysis of variance serum ghrelin, TNF-α and IL-6 in both the CCHD and ACHD groups had a tendency to be higher compared with the control group (all P < 0.05), whereas, on Pearson correlation analysis, there was a correlation between serum ghrelin and BMI (all P < 0.05), and TNF-α was negatively, and IL-6 positively, correlated with BMI (all P < 0.05). Meta-analysis further demonstrated that serum ghrelin, TNF-α and IL-6 in both the CCHD and ACHD groups were higher than in the control group (all P < 0.05).
CONCLUSION: Serum ghrelin, TNF-α and IL-6 are elevated in children with CHD, and may play a role in the development and progression of CHD.
METHOD: Sixty-three children with CHD, hospitalized between January 2012 and September 2014 at Wuhan Women and Children's Health Care Center, were selected as the study group. Additionally, 28 healthy individuals who had physical examinations at this hospital were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum ghrelin, TNF-α and IL-6. SPSS 18.0 and Comprehensive Meta-analysis 2.0 were used for data analysis.
RESULTS: There was significant difference in weight, height and body mass index (BMI; all P < 0.05) but not in age or sex (both P > 0.05) between the cyanotic CHD (CCHD), acyanotic CHD (ACHD) and control groups. On one-way analysis of variance serum ghrelin, TNF-α and IL-6 in both the CCHD and ACHD groups had a tendency to be higher compared with the control group (all P < 0.05), whereas, on Pearson correlation analysis, there was a correlation between serum ghrelin and BMI (all P < 0.05), and TNF-α was negatively, and IL-6 positively, correlated with BMI (all P < 0.05). Meta-analysis further demonstrated that serum ghrelin, TNF-α and IL-6 in both the CCHD and ACHD groups were higher than in the control group (all P < 0.05).
CONCLUSION: Serum ghrelin, TNF-α and IL-6 are elevated in children with CHD, and may play a role in the development and progression of CHD.