Journal of pediatric hematology/oncology · 2021
t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?
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Feng Jianhua, Leung Alex W K, Cheng Frankie W T, Lam Grace K S, Chow Terry T W, Ng Margaret H L, Chu Winnie C W, Chan Natalie P H, Li Chi-Kong
Аннотация
BACKGROUND: There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis.
OBSERVATION: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years.
CONCLUSIONS: Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.
OBSERVATION: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years.
CONCLUSIONS: Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.
Предметные рубрики MeSH
Antineoplastic Combined Chemotherapy ProtocolsAntioxidantsChild, PreschoolChromosomes, Human, Pair 1Chromosomes, Human, Pair 22Drug Therapy, CombinationFemaleHumansInfant, NewbornKeratolytic AgentsLeukemia, Megakaryoblastic, AcuteLiver CirrhosisPrognosisTranslocation, GeneticTretinoinalpha-Tocopherol