Journal of dentistry · 2025
Microbiological profile of molars with advanced furcation defects before and after surgical and non-surgical periodontal treatment: A pilot randomized controlled trial.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Santamaria P, Bahal P, Ghuman M, Malaki Z, Redman J, Spratt D, Nibali L
Аннотация
OBJECTIVES: To describe the microbiological composition of subgingival dental plaque of class III periodontal furcation-involved defects (FI) after surgical or non-surgical periodontal therapy.
METHODS: Twenty participants contributed with a class III FI and a periodontally healthy site (HS) each. FI molars were randomised either to repeated non-surgical periodontal treatment (NSPT) (10) or surgical treatment (10). Periodontal clinical parameters and subgingival plaque were collected at baseline and 6 months after the treatment from both furcation and healthy sites. Microbial analysis was conducted by sequencing the V3-V4 region of the 16S rRNA gene.
RESULTS: In total, 80 subgingival plaque samples were analysed. Differences in richness, diversity, oxygen metabolism, microbial composition, were observed when comparing class III furcation defects with HS (p < 0.05) both at baseline and 6 months later. At 6-months, significant reduction in PPD (p < 0.01) and increase of REC (p < 0.01) was detected in surgically treated sites (PPD: 3.55 ± 1.4, REC: 3.95 ± 1.7) compared to NSPT sites (PPD: 5.4 ± 1.3, REC: 2.92 ± 0.98). Higher levels of aerobic genera and an increase of Streptococcus mutans, Streptococcus oralis, and Streptococcus gordonii were detected in surgically treated sites compared to NSPT.
CONCLUSIONS: The microbial composition of class III furcation defects after surgical periodontal therapy showed higher level of aerobic and acidogenic microbial flora compared with furcation defects treated with a non-surgical approach.
CLINICAL SIGNIFICANCE: While surgical treatment of class III furcation defects improves pocket depths, it also leads to an increase in acidogenic microflora potentially predisposing to caries.
METHODS: Twenty participants contributed with a class III FI and a periodontally healthy site (HS) each. FI molars were randomised either to repeated non-surgical periodontal treatment (NSPT) (10) or surgical treatment (10). Periodontal clinical parameters and subgingival plaque were collected at baseline and 6 months after the treatment from both furcation and healthy sites. Microbial analysis was conducted by sequencing the V3-V4 region of the 16S rRNA gene.
RESULTS: In total, 80 subgingival plaque samples were analysed. Differences in richness, diversity, oxygen metabolism, microbial composition, were observed when comparing class III furcation defects with HS (p < 0.05) both at baseline and 6 months later. At 6-months, significant reduction in PPD (p < 0.01) and increase of REC (p < 0.01) was detected in surgically treated sites (PPD: 3.55 ± 1.4, REC: 3.95 ± 1.7) compared to NSPT sites (PPD: 5.4 ± 1.3, REC: 2.92 ± 0.98). Higher levels of aerobic genera and an increase of Streptococcus mutans, Streptococcus oralis, and Streptococcus gordonii were detected in surgically treated sites compared to NSPT.
CONCLUSIONS: The microbial composition of class III furcation defects after surgical periodontal therapy showed higher level of aerobic and acidogenic microbial flora compared with furcation defects treated with a non-surgical approach.
CLINICAL SIGNIFICANCE: While surgical treatment of class III furcation defects improves pocket depths, it also leads to an increase in acidogenic microflora potentially predisposing to caries.