Stroke · 2008
Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal stenosis.
Письмо в редакциюПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Tang Tjun Y, Howarth Simon P S, Miller Sam R, Graves Martin J, U-King-Im Jean-Marie, Li Zhi-Yong, Walsh Stewart R, Patterson Andrew J, Kirkpatrick Peter J, Warburton Elizabeth A, Varty Kevin, Gaunt Michael E, Gillard Jonathan H
Аннотация
BACKGROUND AND PURPOSE: Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)-defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques.
METHODS: Seventy-one patients with an asymptomatic carotid stenosis of > or = 40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods.
RESULTS: No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found.
CONCLUSIONS: Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.
METHODS: Seventy-one patients with an asymptomatic carotid stenosis of > or = 40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods.
RESULTS: No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found.
CONCLUSIONS: Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.