Медицинская библиотека · Biomarkers in medicine · 2024

Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction.

Wang Xuechao, Feng Junjie, Luan Shaohua, Zhou Yong, Zhang Shipan, Su Hongling, Wang Zhongyu

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Аннотация

Objective

To investigate the correlations between CDC42 and T-cell subsets concerning anxiety, depression and quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention.

Methods

Sera from 156 participants were analyzed for CDC42 levels and Th1, Th2, Th17 and Treg cells.

Results

CDC42 correlated with reduced Th1/Th2 and Th17/Treg ratios, lower anxiety and depression, and higher EuroQol visual analog scale (EQ-VAS) score. The Th17/Treg ratio correlated with elevated anxiety, depression, EuroQol-5 dimensions score and decreased EQ-VAS score. The Th1/Th2 ratio was positively related to the EQ-VAS score.

Conclusion

CDC42 correlates with reduced Th1/Th2 and Th17/Treg ratios, reduced anxiety and depression, and improved quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention.

Для цитирования: Wang Xuechao, Feng Junjie, Luan Shaohua, Zhou Yong, Zhang Shipan, Su Hongling, Wang Zhongyu. Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction.. Biomarkers in medicine. 2024. DOI: 10.2217/bmm-2023-0712.

Предметные рубрики MeSH

Humans ST Elevation Myocardial Infarction Quality of Life Depression Th17 Cells Anxiety

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