Joint bone spine · 2002
Bone loss in primary biliary cirrhosis: absence of association with severity of liver disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Le Gars Laurence, Grandpierre Caroline, Chazouillères Olivier, Berenbaum Francis, Poupon Raoul
Аннотация
OBJECTIVES: The aim of the study was to measure the lumbar bone mineral density in women with primary biliary cirrhosis and to evaluate whether bone mineral density was related to the liver disease, hormonal status and corticosteroid use in these women.
METHODS: Bone mineral density of the lumbar spine (L2-L4) was assessed by dual emission X-ray absorptiometry in 40 women with primary biliary cirrhosis. Hormonal, bone and liver status were compared with bone mineral density and analyzed by nonparametric statistical tests.
RESULTS: Bone loss was evidenced in women with primary biliary cirrhosis compared with control age-matched women (Z-score: -0.9 SD), 32.5% had osteoporosis and 32.5% had osteopenia. The main risk factor of bone loss was the hormonal status: T-score was -1 SD in premenopausal women, -1.1 SD in postmenopausal women receiving an hormonal replacementtherapy and - 2.7SD in postmenopausal untreated women. There was no statistically significant relationship between bone mineral density and biological and histological liver characteristics.
CONCLUSION: Primary biliary cirrhosis-associated bone loss was significantly related to postmenopausal estrogen deficiency, and efficiently prevented by hormonal replacement therapy. Interestingly, the severity of primary biliary cirrhosis was not a determinant factor for bone loss in these women.
METHODS: Bone mineral density of the lumbar spine (L2-L4) was assessed by dual emission X-ray absorptiometry in 40 women with primary biliary cirrhosis. Hormonal, bone and liver status were compared with bone mineral density and analyzed by nonparametric statistical tests.
RESULTS: Bone loss was evidenced in women with primary biliary cirrhosis compared with control age-matched women (Z-score: -0.9 SD), 32.5% had osteoporosis and 32.5% had osteopenia. The main risk factor of bone loss was the hormonal status: T-score was -1 SD in premenopausal women, -1.1 SD in postmenopausal women receiving an hormonal replacementtherapy and - 2.7SD in postmenopausal untreated women. There was no statistically significant relationship between bone mineral density and biological and histological liver characteristics.
CONCLUSION: Primary biliary cirrhosis-associated bone loss was significantly related to postmenopausal estrogen deficiency, and efficiently prevented by hormonal replacement therapy. Interestingly, the severity of primary biliary cirrhosis was not a determinant factor for bone loss in these women.